Supporting Information: Optimal cytoplasmic transport in viral infections

Here, we outline the calculation and analysis of first passage times to nuclear entry, starting at a specified state n = 0 near the cell periphery. Again, the qualitative features of our model are insensitive to the details of the rate parameters, and we use the representative values employed in Figure 4. From Eq. 2, the flux into the nucleus at time t is given by Jn∗(t) = lkn∗Pn∗(t). Upon using standard methods [1, 2], we obtain the conditional first passage time distribution G(t) as the conditional probability flux